6 edition of Cyclodextrins and Their Complexes found in the catalog.
August 30, 2006 by Wiley-VCH .
Written in English
|The Physical Object|
|Number of Pages||507|
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About this book Offering comprehensive and up-to-date know-how in one compact book, an experienced editor and top authors cover every aspect of these important molecules from molecular recognition to cyclodextrins as enzyme models.
Offering comprehensive and up-to-date know-how in one compact book, an experienced editor and top authors cover every aspect of these important molecules from molecular recognition to cyclodextrins Author: Helena Dodziuk.
Cyclodextrins and Their Complexes Edited by Helena Dodziuk Cyclodextrins and Their Complexes. Cyclodextrins and Their Inclusion Complexes. Dominique Duchêne.
UMR CNRSPhysico‐Chimie‐Pharmacotechnie‐Biopharmacie, Université Paris‐Sud, Châtenay, Malabry, France. Book Editor(s): Erem Bilensoy. Hacettepe University, Ankara, Turkey. Search for Cited by: By the mids, each of the natural cyclodextrins had been structurally and chemically characterized and many more complexes had been studied.
Since the s, extensive work has been conducted by Szejtli and others exploring encapsulation by cyclodextrins and their derivatives for industrial and pharmacologic applications. Cyclodextrins are cyclic oligosaccharides which are made up of six to eight glucopyranoside units attached by glucosidic bonds at C1 and C4.
Cyclodextrins are capable of forming inclusion complexes with other molecules due to their toroidal shape which is largely hydrophobic. The cover of Friedrich Cramer's book "Einschlussverbindungen" (inclusion compounds), published in Berlin in In this book Cramer describes various types of compounds that are able to form.
The kind of information on CyDs and their complexes that can be provided by NMR studies is discussed in Chapter 9 while Chapter 10 is devoted to the application of other physicochemical methods (UV, circular dichroism, mass spectroscopy, electrochemistry, AFM and STM, etc.) to the elucidation of the structure of CyDs and their complexes.
Cyclodextrins (CDs) are cyclic oligomers of α-1,4-linked D -glucopyranose. Due to their unique structure, marked by a chiral and hydrophobic cavity, CDs have been extensively used as chiral selectors and drug delivery systems. Although cyclodextrins (CDs) have been studied for over years and can be found in at least 35 pharmaceutical products, they are still regarded as novel pharmaceutical excipients.
CDs are oligosaccharides that possess biological properties that are similar to their linear counterparts, but some of their physicochemical properties differ.
Offering comprehensive and up-to-date know-how in one compact book, an experienced editor and top authors cover every aspect of these important molecules from molecular recognition to cyclodextrins as enzyme models.
A variety of cyclodextrin-based molecular structures, with substitutions of either primary or secondary faces of the natural oligosaccharide macrocycles of α- β- or γ-cyclodextrins, have been designed towards innovative applications of self-assembled cyclodextrin nanomaterials.
Amphiphilic cyclodextrins have been obtained by chemical or enzymatic modifications of their macrocycles using. Cyclodextrins are natural oligosaccharides obtained from starch. They were discovered in by Villiers, and attracted major scientific and industrial interests from the late s.
Actually, cyclodextrins are among the most remarkable macrocyclic molecules with major theoretical and practical interest for chemistry and biology. Szejtli, J. () Cyclodextrins and Their Inclusion Complexes. Akadémiai Kiadó, Budapest. has been cited by the following article: TITLE: Spectrofluorometric Study of the Inclusion Complexation of Fluorescent Whitening Agents and β-Cyclodextrins.
Cyclodextrins and their inclusion complexes [Szejtli, József] on *FREE* shipping on qualifying offers. Cyclodextrins and their inclusion complexesCited by: Chapter 5 describes the methods for preparation and characterization of drug/cyclodextrin complexes.
Chapters 6 and 7 are dedicated to the pharmacokinetics, biopharmaceutical and technological aspects of drug/CD complexes. Chapter 8 treats the application and. The article covers the molecules forming the inclusion complexes, cyclodextrins.
General historical facts of implementation of cyclodextrins in multilateral practice are included. Complexes of cyclodextrins with amino acid analytes are produced in the gas phase and are ideal for the study of molecular recognition.
In this Account, we discuss the evidence for the presence of gas-phase inclusion complexes and the nature of the interaction.
The use of cyclodextrins as chiral selectors in gas-phase guest-exchange reactions is illustrated, and the nature of the. Cyclodextrins and their complexes: chemistry, analytical methods, applications. [Helena Dodziuk;] -- Offering comprehensive and up-to-date know-how in one compact book, an experienced editor and top authors cover every aspect of these important molecules from molecular recognition to cyclodextrins.
Carboxymethylated cyclodextrins and their complexes with Pr(III) and Yb(III) as water-soluble chiral NMR solvating agents for cationic compounds. ChiralityNA-NA. DOI: /chir Jian Jiang, Mark J.
MacLachlan. Cationic guest inclusion in widemouthed Schiff base macrocycles. Chemical CommunicationsDOI: Inclusion complexes of protonated propiconazole nitrate (PCZH-NO 3) with three substituted cyclodextrin (CD) derivatives, namely, sulfobutylether-β-CD (SBE7-β-CD), sulfated-β-CD (β-CD-SNa) and monochlorotriazinyl-β-CD (MCT-β-CD), were investigated as new antifungal systems and compared with a previously published complex of PCZH-NO 3 with unsubstituted β-CD.
Cyclodextrins and Their Inclusion Complexes by Szejtli, J.; Nogradi, M. [Translator]; Horvath, K. [Translator]; and a great selection of related books, art and Format: Hardcover. Stabilization and solubilization of lipophilic natural colorants with cyclodextrins.
Dodziuk, H., Ed. () Cyclodextrins and Their Complexes. Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. has been cited by the following article: TITLE: Flavonoids Loaded in Nanocarriers: An Opportunity to Increase Oral Bioavailability and Bioefficacy.
the presence of cyclodextrins because of the formation of water soluble complexes between the dissolved cyclodextrin and the guest molecule.
The stability of the complex form is characterized by the stability (or equilibrium) constant, K s, of the complex. K s = = (1) where k r (M-1 s-1) is the recombination rate constant and k d. Cyclodextrins and their inclusion complexes (Book, )  Get this from a library.
Cyclodextrins and their inclusion complexes. The application of cyclodextrins and their complexes in packaging materials can help not only transport of previously nontransportable foods, but may also prevent, or at least decelerate, the spread of microbial infections.
The number of publications, particularly analytical papers, on. The biological effects of cyclodextrins, important for their use within antimycotic formulations, can be divided into: effects based on the ability of cyclodextrins to form inclusion complexes with endogenous substances (membrane lipids, cellular cholesterol), effects based on formation of inclusion complexes with component parts of fungi cells.
PROPERTIES OF CYCLODEXTRINS AND THEIR COMPLEXES Cyclodextrins are formed during the enzymatic degradation of starch. They are poly- saccharides built from six to eight (o• = 6, ]3 = 7, •/= 8) D-glucose units.
The D-glucose units are covalently linked at the carbon atoms C• and C 4. The radii of the rigid cavities vary from to nm.
Cyclodextrins (CDs) are cyclic oligosaccharides produced by enzymatic degradation of starch. The most common CDs are the main natural ones, α, β and γ, which are constituted of 6, 7 and 8 glucopyranose units, respectively.
The CD structure forms a torus or doughnut ring and the molecule actually exists as a truncated cone. In solution, modified cyclodextrins have been used to construct molecular reactors, as well as molecular, temperature and pH sensors. At surfaces, they form semipermeable membranes and sensor electrodes.
Such exciting fields of chemistry, made possible only through modifications to the natural cyclodextrins, are the subject of this book. Cyclodextrins, since their discovery in the late 19th century, were mainly regarded as excipients. Nevertheless, developments in cyclodextrin research have shown that some of these hosts can capture and include biomolecules, highlighting fatty acids and cholesterol, which implies that they are not inert and that their action may be used in specific medicinal purposes.
Consequently, many chemical modifications of cyclodextrins have been studied in an attempt to overcome their limitations and improve their technological characteristics.
Well-structured molecules as well as random mixtures are described in the literature [ 4 ], and dimers [ 5 ], trimers [ 6 ], and polymers have also been obtained [ 7 ]. Sulfated and carboxymethylated cyclodextrins and their lanthanide complexes as chiral NMR discriminating agents.
natural cyclodextrins frequently form B-type profiles. Most drug/cyclodextrin complexes are thought to be inclusion complexes but cyclodextrins are also known to form non-inclusion complexes and complex aggregates capable to dissolve drugs through micelle-like structures.
The phase-solubility profiles do not verify formation of inclusion complexes. The contents of this volume originate from the joint Inclusion Phenomenal Cyclodextrins Symposium held at Lancaster in July Consisting of 50 extended ab stracts and 21 original contributions, the reader will find an up-to-date survey of the current state of research into, and applications.
Cyclodextrins: Properties and Industrial Applications is a comprehensive resource that includes information on cyclodextrins (CDs) structure, their properties, formation of inclusion complex with various compounds as well as their applications. The authors Sahar Amiri and Sanam Amiri, noted experts in the field of cyclodextrins, cover both the.
Interaction of Native Cyclodextrins and Their Hydroxypropylated Derivatives with Carbamazepine in Aqueous Solution. Evaluation of Inclusion Complexes and Aggregates Formation. Rodrigues Sá Couto A(1), Ryzhakov A(1), Larsen KL(2), Loftsson T(1). Cyclodextrins are useful molecular chelating agents including some organic molecules within a cavity formed by their ring-shaped structure.
For this reason cyclodextrins are widely used as drug carrier in food and flavors, cosmetics, packing, textiles, separation processes, environment protection, fermentation and catalysis but also form.
tion of an inclusion complex, often a interaction, is usually described by Equation 1 or as in Scheme 1, although higher order complexes are often seen or postulated. (1) INTRODUCTION This short review will address a number of issues associated with the use of cyclodextrins (CDs) to enhance the formulation and delivery of problematic drugs.
Despite the wide range of potential applications of these bio-based compounds, their practical use is still limited due to many reasons such as poor aqueous solubility, volatility, reactivity, etc.
Generally, when complexed with cyclodextrins, these bio-based compounds enhance considerably their performance and potential applications.Ryzhakov A, DoThi T, Stappaerts J, Bertoletti L, Kimpe K, Rodrigues Sa Couto A et al. Self-assembly of cyclodextrins and their complexes in aqueous solutions.
Journal of Pharmaceutical Sciences. ;(9) Cyclodextrins are cyclic oligomers of glucose; these compounds form inclusion complexes with any drug whose molecule can fit into the lipophile-seeking cavities of the cyclodextrin molecule. Cyclodextrins are crystalline and so are their complexes with drugs, and these complexes have somewhat improved water solubilities compared to the drugs.